This proves that a PCL scaffold with higher porosity is a potential replacement for Bruch's membrane. The results show that the scaffold with higher porosity has a lower pressure gradient which is necessary for RPE cell adherence and is mechanically stable. The analysis was carried out for scaffolds with different porosity. The model has a square geometry with a dimension of 100 × 100 × 4 μm through which blood was allowed to flow from bottom to top across the geometry. In this study, a scaffold made of porous poly (caprolactone) (PCL) was designed using the tool COMSOL Multiphysics and its properties like structural integrity and the fluid flow were analysed using Brinkman's equation.
Treatment for AMD is to replace Bruch's membrane with scaffolds that provide conducive environment for the RPE cells to adhere and proliferate. It is characterised by the loss of retinal pigment epithelial (RPE) cells from the macula of eye due to the deposition of drusen in the Bruch's membrane that supports the RPE cells. Title: Modelling and simulation analysis of porous polymeric scaffold for the replacement of Bruch's membrane as a therapy for age-related macular degenerationĪuthors: Susan Immanuel Aswin Bob Ignatius Alagappan MuthuppalaniappanĪddresses: Department of Electronics and Communication Engineering, PSG College of Technology, Coimbatore 641004, Tamilnadu, India ' Department of Electronics and Communication Engineering, PSG College of Technology, Coimbatore 641004, Tamilnadu, India ' Department of Electronics and Communication Engineering, PSG College of Technology, Coimbatore 641004, Tamilnadu, IndiaĪbstract: Age related macular degeneration (AMD) is a common disease that is prevalent among people of age 50. International Journal of Biomedical Engineering and Technology.Inderscience Publishers - linking academia, business and industry through research Article: Modelling and simulation analysis of porous polymeric scaffold for the replacement of Bruch's membrane as a therapy for age-related macular degeneration Journal: International Journal of Biomedical Engineering and Technology (IJBET) 2020 Vol.33 No.3 pp.290 - 304 Abstract: Age related macular degeneration (AMD) is a common disease that is prevalent among people of age 50.
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